When it comes to optimising wellness, the spleen doesn’t usually get top billing. It's not as headline-grabbing as your brain or heart, not as trend-friendly as your gut. But in recent years, biohackers and integrative health experts have started paying attention to this strange, spongy organ sitting quietly under your ribs, and for good reason.
From immune regulation and blood filtration to detoxification and even red blood cell recycling, the spleen has far more to do with your overall vitality than most people realise. And if you’re someone taking supplements to improve focus, energy, or ageing gracefully, supporting spleen function may be an unexpectedly smart move.
Let’s take a closer look at why the spleen is having a wellness moment, and what it might mean for your stack.
What Does the Spleen Actually Do?
The spleen is the largest organ in the lymphatic system, a key part of your immune network and fluid balance. It performs several under-the-radar but vital jobs:
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Filters and recycles old red blood cells
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Stores and releases white blood cells (especially monocytes) during infection
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Acts as a reservoir for blood (helpful in emergencies like injury or intense exertion)
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Supports immune surveillance by detecting and responding to pathogens
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Helps manage inflammation and clear cellular debris
In short, the spleen is like a biological gatekeeper, one that screens your blood for threats, manages your immune army, and keeps things flowing smoothly in the background.
Why the Spleen Matters for Energy and Brain Health
While it doesn’t directly generate energy or produce neurotransmitters, a sluggish spleen can still affect how energised and clear-headed you feel.
Here’s how:
1. Blood Quality and Oxygenation
The spleen recycles old red blood cells and helps maintain blood integrity. If this process is impaired, your circulation and oxygen delivery can suffer, which means your mitochondria (the energy factories in your cells) may not work as efficiently.
Inadequate oxygen transport = less ATP production = fatigue, brain fog, poor endurance.
2. Inflammation Clearance
Your spleen filters out damaged cells, debris, and cytokines, molecules that ramp up inflammation. If your spleen is underfunctioning, this inflammatory “trash” can accumulate, leading to low-grade systemic inflammation, which is linked to accelerated ageing, brain fatigue, and poor recovery.
3. Immune-Brain Connection
A properly functioning spleen helps modulate the immune system, preventing it from overreacting. Chronic immune activation, sometimes called "inflammaging", has been linked to depression, slower cognition, and neurodegenerative risk. By keeping immune signals balanced, your spleen may indirectly support brain health.
Eastern Medicine Has Long Known This
In Traditional Chinese Medicine (TCM), the spleen is considered a major organ in digestion, immunity, and vitality. But TCM’s spleen isn’t exactly the same as the anatomical one in Western medicine, it also includes aspects of the pancreas and stomach.
In TCM, a weak spleen is associated with:
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Chronic fatigue
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Brain fog
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Loose stools or digestive bloating
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Cold limbs
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Poor concentration
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Easy bruising or bleeding
Many of these symptoms overlap with signs of poor methylation, low NAD+ levels, or sluggish detoxification, areas that are central to modern nootropic and longevity protocols.
While Eastern and Western models differ, the renewed interest in spleen function suggests that the organ’s quiet influence has been underappreciated.
How Can You Tell If Your Spleen Needs Support?
The spleen doesn’t usually cause symptoms until there’s a serious issue (like infection or enlargement), but there are subtle clues your spleen-lymph-immune system might be under strain:
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You get sick easily or take longer to recover
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Chronic low energy despite good sleep and nutrition
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Brain fog, especially in the afternoon
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Mild but persistent digestive issues
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Skin rashes or histamine reactions
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Poor circulation or always feeling cold
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Trouble recovering from physical exertion
If these sound familiar—, nd you’ve ruled out major causes like iron deficiency or thyroid dysfunction, it might be time to give your lymphatic system some love.
How the Spleen Ties Into Detox and Methylation
The spleen is part of the reticuloendothelial system, a network of cells and organs that clears dead cells, pathogens, and metabolic waste. This overlaps with how your methylation pathways work to process toxins, synthesise neurotransmitters, and manage DNA repair.
When you take NAD+ boosters like NMN, your metabolism ramps up. This is good, but it also increases demand on systems that clear byproducts. Methylation supports this, and TMG (trimethylglycine) is one of the most efficient methyl donors available.
If your detox or methylation systems are sluggish, your spleen might have to work harder to filter out inflammatory or immune waste from that metabolic surge, leading to subtle but compounding effects.
So if you're taking NAD+ boosters and feel “wired but tired,” sluggish, or inflamed, adding support for your spleen and lymphatic system may help your body process these changes more efficiently.
How to Support Spleen Health (and Why Biohackers Care)
Some of the most vocal figures in the longevity space, from Bryan Johnson to high-performance athletes, are now paying closer attention to overlooked systems like the spleen, liver, and lymph.
Here’s how to give your spleen a gentle but effective upgrade:
1. Movement, Especially Bouncing or Rebounding
Unlike your cardiovascular system, your lymphatic system (which includes the spleen) doesn’t have a pump. It relies on muscle contractions and gravity to keep fluids moving.
Rebounding (on a mini trampoline), brisk walking, or even jumping rope for a few minutes a day can stimulate spleen-lymph flow.
2. Hydration
Simple, but often forgotten. Lymph fluid is mostly water. If you're even slightly dehydrated, filtration slows down.
Try adding trace minerals or electrolytes if you drink lots of filtered water: overfiltration can strip beneficial ions.
3. Nutrient Support: TMG + Choline + B Vitamins
Support methylation pathways and cellular detox with:
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TMG (Trimethylglycine): donates methyl groups, supports liver and detox
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Choline: supports bile flow, liver health, and cell membrane function
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Vitamin B6/B12/Folate: co-factors in methylation and energy metabolism
This stack supports the liver-spleen-detox triangle, especially if you’re using NAD+ precursors like NMN.
That’s why we created our TMG + B-Complex formula: to make daily detox and methylation support easy, reliable, and stackable. It combines Trimethylglycine (TMG) with active forms of B6, B12, and Choline, cofactors your body uses to support detox, process NAD+ precursors like NMN, and keep inflammation in check.
If you’re already investing in your energy, clarity, or ageing well, our TMG + B-Complex formula is a foundational layer that helps everything else work better.
